Transposable Elements and Stress in Vertebrates: An Overview

Since their identification as genomic regulatory elements, Transposable Elements (TEs) were considered, at first, molecular parasites and later as an important source of genetic diversity and regulatory innovations. In vertebrates in particular, TEs have been recognized as playing an important role in major evolutionary transitions and biodiversity. Moreover, in the last decade, a significant number of papers has been published highlighting a correlation between TE activity and exposition to environmental stresses and dietary factors. In this review we present an overview of the impact of TEs in vertebrate genomes, report the silencing mechanisms adopted by host genomes to regulate TE activity, and finally we explore the effects of environmental and dietary factor exposures on TE activity in mammals, which is the most studied group among vertebrates. The studies here reported evidence that several factors can induce changes in the epigenetic status of TEs and silencing mechanisms leading to their activation with consequent effects on the host genome. The study of TE can represent a future challenge for research for developing effective markers able to detect precocious epigenetic changes and prevent human diseases.     

涪陵地区茅三段热液白云岩展布影响因素分析

针对热液白云岩展布非均质性强的问题,开展基底断裂与茅三段沉积演化关系研究,分析断裂样式与白云岩分布关系,建立沉积演化模式,预测白云岩的分布。研究结果表明:茅三段可划分为5个小层,1~3小层为白云岩发育主要时期,4~5小层为台地均一化时期,不发育白云岩;15-1、15-2和16号基底断裂控制了早期“台-洼”相间的沉积地貌,断裂附近的地貌高部位为生屑滩发育有利部位,为白云岩的发育提供物质基础;15-1、15-2号基底断裂样式为花状,周边生屑滩白云石化程度高,为白云岩发育最有利区;16号基底断裂为直立状,附近白云石化发育程度较低,为白云岩发育较有利区。研究成果可为热液白云岩领域的进一步勘探提供指导依据。     

我国MTBE的生产使用现状及趋势分析

对我国MTBE的生产工艺及下游产品进行了详细的分析,重点分析了影响MTBE产品生产使用的各方面因素,从能源方针、车用燃料政策及环保要求等角度对我国MTBE产品的未来发展趋势进行了预测分析。结果显示,2020年以后我国汽油调和用MTBE的生产使用量将逐步降低,但此过程可能会较为平缓。     

高职院校学生创业意向影响因素研究

采取简单随机方法,从菏泽家政职业学院各个系随机选取6个班,以笔者自拟的调查问卷对该6个班的全体学生进行问卷调查,并采用二元logistic回归分析对问卷调查的结果进行多因素分析,最后得出结论,性别、所学专业、专业知识和技能、家人态度、创业资金来源、他人影响对高职院校学生创业意向的影响不显著,而内控制源、创业能效感、风险忍耐度、政府支持对高职院校学生创业意向有显著影响。     

Muddling between science and engineering: an epistemic strategy for developing human factors and ergonomics as a hybrid discipline

Human Factors and Ergonomics (HFE) recognises itself as a design-driven, systemic and scientific discipline geared towards well-being and performance. Being a scientific discipline and design-oriented requires that the epistemic basis of science and design/engineering be fully comprehended. In interdisciplinary research where these two viewpoints meet, there are often dilemmas posed in terms of knowledge construction and labelling of activity. Therefore, this article scrutinises these two orientations and addresses the differences and commonalities, using case studies from engineering and psychological science (both constituents of HFE). Based on these insights, a way forward is suggested in terms of (1) a reflexive engagement with epistemic concepts and methods; (2) finding a conceptual space for balancing and bridging the science-engineering divide; (3) comprehending ‘design-thinking/design knowledge’ and not treating it as an application of science; (4) providing emphasis on problem formulation and practices of HFE focusing on developing them in systemic terms.     

基于灰色关联度的微孔端面机械密封开启力共性影响参数分析

目前微孔端面机械密封采用的几何参数繁多,缺乏明确物理意义。为找出跨孔型的共性几何参数,基于Fluent多相流空化模型,针对矩形孔、菱形孔、椭圆孔端面机械密封,建立密封间隙流体的三维数值计算模型,计算得到144条开启力数据;在分析开启力和几何尺寸之间的关系、额外开启力产生机制的基础上,提出等效长度和等效宽度2个具有物理意义的几何参数;采用灰色关联度分析法,分析和验证等效长度、等效宽度、方向角、面积比对开启力的影响,发现4个因素对3种微孔密封的间隙流体开启力都有影响,但等效长度与等效宽度的影响较方向角、面积比大。